Article
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.
PLoS neglected tropical diseases - 1 Dec 2016
Fernandez-Prada Christopher, Vincent Isabel M, Brotherton Marie-Christine, Roberts Mathew, Roy Gaétan, Rivas Luis, Leprohon Philippe, Smith Terry K, Ouellette Marc
Abstract excerpt
Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmaniasis in endemic regions of India. Resistance to MF can be due to point mutations in the miltefosine transporter (MT). Here we show that mutations in MT are also...
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