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Article

Mutational analysis of PRNP in Alzheimer's disease and frontotemporal dementia in China.

Scientific reports - 2 Dec 2016

Zhang Weiwei, Jiao Bin, Xiao Tingting, Pan Chuzheng, Liu Xixi, Zhou Lin, Tang Beisha, Shen Lu

Abstract excerpt

The prion protein (PRNP) gene is associated with prion diseases, whereas variants of the PRNP gene may also explain some cases of Alzheimer disease (AD) and frontotemporal dementia (FTD) in Caucasian populations. To determine the prevalence of the PRNP gene in patients with AD and FTD in China, we screened all exons of the PRNP gene in a cohort of 683 cases (606 AD and 77 FTD) in the Chinese Han population and we...

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Source

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Identifiers

PMID: 27910931
DOI: 10.1038/srep38435
PMCID: PMC5133586

Genes

PRNP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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