Article
PRNP mutations in a series of apparently sporadic neurodegenerative dementias in China.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Zheng Liu, Longfei Jia, Jing Ye, Xinqing Zhang, Haiqing Song, Haiyan Lv, Fen Wang, Xiumin Dong, Jianping Jia
Abstract excerpt
Mutations in prion protein gene (PRNP) may lead to genetic prion disease, which usually has a broad range of phenotypic presentations that overlap with other neurodegenerative dementias. In this study, we screened the PRNP gene to evaluate the frequency of PRNP mutations and their correlations with clinical phenotype in 185 sporadic neurodegenerative dementia cases and 310 control subjects. Samples of DNA from...
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