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Article

A case of dementia with PRNP D178Ncis-129M and no insomnia.

Alzheimer disease and associated disorders - 1 Jan 2000

Guerreiro Rita J, Vaskov Tina, Crews Cynthia, Singleton Andrew, Hardy John

Abstract excerpt

OBJECTIVE: To describe a dementia case clinically diagnosed as Alzheimer disease with a PRNP genotype usually associated with familial fatal insomnia. METHODS: Polymerase chain reaction amplification and subsequent direct sequencing of PGRN, MAPT, PSEN1, PSEN2, APP, and PRNP genes. RESULTS: A point mutation (D178N) was found in the PRNP gene. CONCLUSIONS: The mutation D178N in the PRNP gene associated with the...

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Source

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Identifiers

PMID: 19571725
DOI: 10.1097/WAD.0b013e3181ae3a76
PMCID: PMC2787867

Genes

PRNP
APP
MAPT
PSEN1
PSEN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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