Article
In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription.
PloS one - 1 Jan 2016
Bruske Ellen Inga, Dimonte Sandra, Enderes Corinna, Tschan Serena, Flötenmeyer Matthias, Koch Iris, Berger Jürgen, Kremsner Peter, Frank Matthias
Abstract excerpt
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is considered to be the main variant surface antigen (VSA) of Plasmodium falciparum and is mainly localized on electron-dense knobs in the membrane of the infected erythrocyte. Switches in PfEMP1 expression provide the basis for antigenic variation and are thought to be critical for parasite persistence during chronic infections. Recently, strain...
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