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Article

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease.

European archives of psychiatry and clinical neuroscience - 1 Aug 2017

Kronenberg Golo, Uhlemann Ria, Schöner Johanna, Wegner Stephanie, Boujon Valérie, Deigendesch Nikolas, Endres Matthias, Gertz Karen

Abstract excerpt

Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia activation states and telomere biology. A panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models...

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Identifiers

PMID: 27896432
DOI: 10.1007/s00406-016-0750-1
PMCID: PMC5509772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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