Article
Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families.
Journal of diabetes research - 1 Jan 2016
Kulkarni Hemant, Mamtani Manju, Peralta Juan Manuel, Diego Vincent, Dyer Thomas D, Goring Harald, Almasy Laura, Mahaney Michael C, Williams-Blangero Sarah, Duggirala Ravindranath, Curran Joanne E, Blangero John
Abstract excerpt
SLC30A8 encodes zinc transporter 8 which is involved in packaging and release of insulin. Evidence for the association of SLC30A8 variants with type 2 diabetes (T2D) is inconclusive. We interrogated single nucleotide polymorphisms (SNPs) around SLC30A8 for association with T2D in high-risk, pedigreed individuals from extended Mexican American families. This study of 118 SNPs within 50 kb of the SLC30A8 locus...
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