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Article

Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion.

Nature medicine - 1 Jan 2017

Chun Sungkun, Du Fei, Westmoreland Joby J, Han Seung Baek, Wang Yong-Dong, Eddins Donnie, Bayazitov Ildar T, Devaraju Prakash, Yu Jing, Mellado Lagarde Marcia M, Anderson Kara, Zakharenko Stanislav S

Abstract excerpt

Although 22q11.2 deletion syndrome (22q11DS) is associated with early-life behavioral abnormalities, affected individuals are also at high risk for the development of schizophrenia symptoms, including psychosis, later in life. Auditory thalamocortical (TC) projections recently emerged as a neural circuit that is specifically disrupted in mouse models of 22q11DS (hereafter referred to as 22q11DS mice), in which...

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Identifiers

PMID: 27892953
DOI: 10.1038/nm.4240
PMCID: PMC5218899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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