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Article

Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer

10 Dec 2022

Abstract excerpt

Despite improvements in preventative strategies, such as regular screenings with Pap tests and human papillomavirus (HPV) tests as well as HPV vaccinations, effective treatment for advanced cervical cancer remains poor. Deregulation of STAT3 is an oncogenic factor that promotes tumorigenesis and epithelial-to-mesenchymal transition (EMT) in various cancers. Oncostatin M (OSM), a pleiotropic cytokine, induces...

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PMID: 36551576
DOI: 10.3390/cancers14246090

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Related research

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Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical CancerPMID 36551576Read ↗

Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.Semantic proximity Read ↗

Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma via STAT3 in pan-cancer analysisSemantic proximity Read ↗

Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro‐angiogenic phenotype and increased cell motility and invasivenessSemantic proximity Read ↗

Multi-omic profiling identifies malignant subpopulations and a hypoxia-driven angiogenic axis as therapeutic vulnerabilities in sinonasal squamous cell carcinomaSemantic proximity Read ↗

Stromal Oncostatin M axis promotes breast cancer progressionSemantic proximity Read ↗

Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcomeSemantic proximity Read ↗

Oncostatin M receptor overexpression promotes tumour progression in squamous cell carcinoma, via hypoxia signalling and multiple effects on the tumour microenvironmentSemantic proximity Read ↗

VGLL3 expression is associated with macrophage infiltration and predicts poor prognosis in epithelial ovarian cancerSemantic proximity Read ↗

STAT3-mediated SMAD3 activation underlies Oncostatin M-induced SenescenceSemantic proximity Read ↗

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transitionSemantic proximity Read ↗

Hypoxia-induced Semaphorin 6B promotes the development of cervical cancer through regulating macrophage polarizationSemantic proximity Read ↗

Oncostatin M orchestrates collective epithelial migration via HIF1A activationSemantic proximity Read ↗

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