Article
GWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration.
Scientific reports - 28 Nov 2016
Riaz Moeen, Lorés-Motta Laura, Richardson Andrea J, Lu Yi, Montgomery Grant, Omar Amer, Koenekoop Robert K, Chen John, Muether Philipp, Altay Lebriz, Schick Tina, Fauser Sascha, Smailhodzic Dzenita, van Asten Freekje, de Jong Eiko K, Hoyng Carel B, Burdon Kathryn P, MacGregor Stuart, Guymer Robyn H, den Hollander Anneke I, Baird Paul N
Abstract excerpt
Pooled DNA based GWAS to determine genetic association of SNPs with visual acuity (VA) outcome in anti-vascular endothelial growth factor (anti-VEGF) treated neovascular age-related macular degeneration (nAMD) patients. We performed pooled DNA based GWAS on 285 anti-VEGF treated nAMD patients using high density Illumina 4.3 M array. Primary outcome was change in VA in Early Treatment Diabetic Retinopathy Study...
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