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Article

Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish.

Scientific reports - 28 Nov 2016

Khatri Deepak, Zizioli Daniela, Tiso Natascia, Facchinello Nicola, Vezzoli Sara, Gianoncelli Alessandra, Memo Maurizio, Monti Eugenio, Borsani Giuseppe, Finazzi Dario

Abstract excerpt

Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase (COASY), genes involved in CoA biosynthesis, are associated with rare neurodegenerative disorders with brain iron accumulation. We showed that zebrafish pank2 gene plays an essential role in brain and vasculature development. Now we extended our study to coasy. The gene has high level of sequence identity with the human ortholog and is ubiquitously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27892483
DOI: 10.1038/srep37660
PMCID: PMC5124858

Genes

COASY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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