Article
Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease.
Neurobiology of disease - 1 Jan 2016
Zizioli Daniela, Tiso Natascia, Guglielmi Adele, Saraceno Claudia, Busolin Giorgia, Giuliani Roberta, Khatri Deepak, Monti Eugenio, Borsani Giuseppe, Argenton Francesco, Finazzi Dario
Abstract excerpt
Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenerative phenotype observed in PKAN patients is still poorly understood. We exploited the zebrafish model to study the role played...
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