Article
CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis.
Journal of the American Medical Directors Association - 1 Jan 2017
Ham Annelies C, Ziere Gijsbertus, Broer Linda, Swart Karin M A, Enneman Anke W, van Dijk Suzanne C, van Wijngaarden Janneke P, van der Zwaluw Nikita L, Brouwer-Brolsma Elske M, Dhonukshe-Rutten Rosalie A M, van Schoor Natasja M, Zillikens M Carola, van Gelder Teun, de Vries Oscar J, Lips Paul, Deeg Dorly J H, de Groot Lisette C P G M, Hofman Albert, Witkamp Renger F, Uitterlinden André G, Stricker Bruno H, van der Velde Nathalie
Abstract excerpt
OBJECTIVE: To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk. DESIGN: Three prospective studies; the Rotterdam Study, B-PROOF, and LASA. SETTING: Community-dwelling individuals living in or near five Dutch cities. PARTICIPANTS: There were 11,485 participants aged ≥55 years. MEASUREMENTS: Fall incidents were recorded prospectively. Benzodiazepine use was determined using...
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