Article
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
Human molecular genetics - 1 May 2018
Teslovich Tanya M, Kim Daniel Seung, Yin Xianyong, Stancáková Alena, Jackson Anne U, Wielscher Matthias, Naj Adam, Perry John R B, Huyghe Jeroen R, Stringham Heather M, Davis James P, Raulerson Chelsea K, Welch Ryan P, Fuchsberger Christian, Locke Adam E, Sim Xueling, Chines Peter S, Narisu Narisu, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Gudnason Vilmundur, Musani Solomon K, Jarvelin Marjo-Riitta, Schellenberg Gerard D, Speliotes Elizabeth K, Kuusisto Johanna, Collins Francis S, Boehnke Michael, Laakso Markku, Mohlke Karen L
Abstract excerpt
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serum amino acids (alanine, glutamine, glycine, histidine, isoleucine, leucine,...
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