Article
The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection.
Journal of virology - 1 Feb 2017
Ma Hongfang, Jiang Longguang, Qiao Songlin, Zhi Yubao, Chen Xin-Xin, Yang Yanyan, Huang Xiaojing, Huang Mingdong, Li Rui, Zhang Gai-Ping
Abstract excerpt
Porcine reproductive and respiratory syndrome (PRRS) has become an economically critical factor in swine industry since its worldwide spread in the 1990s. Infection by its causative agent, PRRS virus (PRRSV), was proven to be mediated by an indispensable receptor, porcine CD163 (pCD163), and the fifth scavenger receptor cysteine-rich domain (SRCR5) is essential for virus infection. However, the structural details...
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