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Article

NF-kappaΒ-inducing kinase regulates stem cell phenotype in breast cancer.

Scientific reports - 23 Nov 2016

Vazquez-Santillan Karla, Melendez-Zajgla Jorge, Jimenez-Hernandez Luis Enrique, Gaytan-Cervantes Javier, Muñoz-Galindo Laura, Piña-Sanchez Patricia, Martinez-Ruiz Gustavo, Torres Javier, Garcia-Lopez Patricia, Gonzalez-Torres Carolina, Ruiz Victor, Avila-Moreno Federico, Velasco-Velazquez Marco, Perez-Tapia Mayra, Maldonado Vilma

Abstract excerpt

Breast cancer stem cells (BCSCs) overexpress components of the Nuclear factor-kappa B (NF-κB) signaling cascade and consequently display high NF-κB activity levels. Breast cancer cell lines with high proportion of CSCs exhibit high NF-κB-inducing kinase (NIK) expression. The role of NIK in the phenotype of cancer stem cell regulation is poorly understood. Expression of NIK was analyzed by quantitative RT-PCR in...

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Identifiers

PMID: 27876836
DOI: 10.1038/srep37340
PMCID: PMC5120353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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