Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course-based undergraduate research experience in molecular and cell biology.

doi:10.1002/bmb.21024

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course-based undergraduate research experience in molecular and cell biology.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology - 4 Mar 2017

Hekmat-Scafe Daria S, Brownell Sara E, Seawell Patricia Chandler, Malladi Shyamala, Imam Jamie F Conklin, Singla Veena, Bradon Nicole, Cyert Martha S, Stearns Tim

Abstract excerpt

The opportunity to engage in scientific research is an important, but often neglected, component of undergraduate training in biology. We describe the curriculum for an innovative, course-based undergraduate research experience (CURE) appropriate for a large, introductory cell and molecular biology laboratory class that leverages students' high level of interest in cancer. The course is highly collaborative and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomedical Research

Share to Genes, Tumor Suppressor

Share to Laboratories

Share to Molecular Biology

Share to Saccharomyces cerevisiae

Share to Students

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 27873457
DOI: 10.1002/bmb.21024
PMCID: PMC5516179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course-based undergraduate research experience in molecular and cell biology.PMID 27873457Read ↗

Functional analysis of p53 tumor suppressor in yeast.Semantic proximity Read ↗

Isolation and characterization of Saccharomyces cerevisiae mutants defective in chromosome transmission in an undergraduate genetics research course.Semantic proximity Read ↗

Using an international p53 mutation database as a foundation for an online laboratory in an upper level undergraduate biology class.Semantic proximity Read ↗

A course-based undergraduate research experience investigating p300 bromodomain mutations.Semantic proximity Read ↗

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysisSemantic proximity Read ↗

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.Semantic proximity Read ↗

CUR(E)ating a New Approach to Study Fungal Effectors and Enhance Undergraduate Education through Authentic ResearchSemantic proximity Read ↗

From genes to proteins to behavior: a laboratory project that enhances student understanding in cell and molecular biology.Semantic proximity Read ↗

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutantsSemantic proximity Read ↗

A course-based undergraduate research experience investigating the consequences of nonconserved mutations in lactate dehydrogenase.Semantic proximity Read ↗

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.Semantic proximity Read ↗

Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.