Article
Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis.
BMC cancer - 21 Nov 2016
Savage Philip
Abstract excerpt
BACKGROUND: Cytotoxic chemotherapy brings routine cures to only a small select group of metastatic malignancies comprising gestational trophoblast tumours, germ cell tumours, acute leukemia, Hodgkin's disease, high grade lymphomas and some of the rare childhood malignancies. We have previously postulated that the extreme sensitivity to chemotherapy for these malignancies is linked to the on-going high levels of...
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