Article
Tubular Cytoplasmic Expression of Zinc Finger Protein SNAI1 in Renal Transplant Biopsies: A Sign of Diseased Epithelial Phenotype?
The American journal of pathology - 1 Jan 2017
Prunotto Marco, Chaykovska Lyubov, Bongiovanni Massimo, Frattini Milo, Cagarelli Thomas, Weibel Franziska, Bruschi Maurizio, de Herreros Antonio Garcia, Moll Solange
Abstract excerpt
The aim of the present study was to analyze in vivo the role of zinc finger protein SNAI1 (SNAI1) on renal fibrosis. Unilateral ureteral obstruction injury was induced in Snai1 knockout mice. Snai1 gene deletion was, however, only partial and could therefore not be correlated to reduced fibrosis. Expression of SNAI1 protein and epithelial-mesenchymal transformation markers was then assessed in human chronic...
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