Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer predisposition syndromes: lessons for truly precision medicine.

The Journal of pathology - 1 Jan 2017

Glaire Mark A, Brown Matthew, Church David N, Tomlinson Ian

Abstract excerpt

Cancer predisposition syndromes are typically uncommon, monogenic, high-penetrance disorders. Despite their rarity, they have proven to be highly clinically relevant in directing cancer prevention strategies. As such, they share notable similarities with an expanding class of low-frequency somatic mutations that are associated with a striking prognostic or predictive effect in the tumours in which they occur. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Precision Medicine

Share to Prognosis

Source

Identifiers

PMID: 27859368
DOI: 10.1002/path.4842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer predisposition syndromes: lessons for truly precision medicine.PMID 27859368Read ↗

Translating Germline Cancer Risk into Precision Prevention.Semantic proximity Read ↗

Hereditary cancer predisposition syndromes.Semantic proximity Read ↗

Advances in the recognition and management of hereditary cancer.Semantic proximity Read ↗

Aligning Germline Cancer Predisposition With Tumor-Based Next-Generation Sequencing for Modern Oncology Diagnosis, Interception, and Therapeutic DevelopmentSemantic proximity Read ↗

The origins, determinants, and consequences of human mutations.Semantic proximity Read ↗

Genetic causes of cancer predisposition in children and adolescents.Semantic proximity Read ↗

Precision medicine in heritable cancer: when somatic tumour testing and germline mutations meetSemantic proximity Read ↗

Genetics of cancer predisposition and progression.Semantic proximity Read ↗

Genetic tumor syndromes in female cancer: insights into inherited cancer predisposition and clinical implications.Semantic proximity Read ↗

Cancer predisposition syndromes.Semantic proximity Read ↗

Molecular methods in cancer diagnostics: a short review.Semantic proximity Read ↗

Genetic cancer predisposition syndromes among older adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.