Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of false positive mutations in BRCA gene by next generation sequencing.

Familial cancer - 1 Jul 2017

Suryavanshi Moushumi, Kumar Dushyant, Panigrahi Manoj Kumar, Chowdhary Meenakshi, Mehta Anurag

Abstract excerpt

BRCA1 and BRCA2 genes are implicated in 20-25% of hereditary breast and ovarian cancers. New age sequencing platforms have revolutionized massively parallel sequencing in clinical practice by providing cost effective, rapid, and sensitive sequencing. This study critically evaluates the false positives in multiplex panels and suggests the need for careful analysis. We employed multiplex PCR based BRCA1 and BRCA2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to False Positive Reactions

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to High-Throughput Nucleotide Sequencing

Share to Multiplex Polymerase Chain Reaction

Source

Identifiers

PMID: 27848044
DOI: 10.1007/s10689-016-9955-8

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of false positive mutations in BRCA gene by next generation sequencing.PMID 27848044Read ↗

Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

Evaluation of an amplicon-based next-generation sequencing panel for detection of BRCA1 and BRCA2 genetic variants.Semantic proximity Read ↗

Multiple Mutation Detection for Risk Assessment in Patients with Breast Cancer by Using Next-Generation Sequencing.Semantic proximity Read ↗

BRCA1 and BRCA2 gene mutation spectrum and high frequency of BRCA1 185delAG among breast and ovarian cancer patients from Southern India.Semantic proximity Read ↗

Development of a next-generation sequencing method for BRCA mutation screening: a comparison between a high-throughput and a benchtop platform.Semantic proximity Read ↗

Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology.Semantic proximity Read ↗

BRCA1 and BRCA2 gene mutation spectrum and a high frequency of BRCA1 185delAG among breast and ovarian cancer patients from Southern India.Semantic proximity Read ↗

Targeted Next-generation Sequencing for Reliable Detection of Genetic Status in Breast Cancer.Semantic proximity Read ↗

BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report.Semantic proximity Read ↗

Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.Semantic proximity Read ↗

Genetic testing in hereditary breast and ovarian cancer using massive parallel sequencing.Semantic proximity Read ↗

Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.