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Article

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

27 Mar 2008

Abstract excerpt

OBJECTIVE: MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression. In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue. METHODS: Locked nucleic acid microarray was used to screen for differentially expressed miRNA in RASFs treated with tumor necrosis factor...

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PMID: 18383392
DOI: 10.1002/art.23386

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