Article
MEN1 redefined, a clinical comparison of mutation-positive and mutation-negative patients.
BMC medicine - 15 Nov 2016
de Laat Joanne M, van der Luijt Rob B, Pieterman Carolina R C, Oostveen Maria P, Hermus Ad R, Dekkers Olaf M, de Herder Wouter W, van der Horst-Schrivers Anouk N, Drent Madeleine L, Bisschop Peter H, Havekes Bas, Vriens Menno R, Valk Gerlof D
Abstract excerpt
BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) is diagnosed when two out of the three primary MEN1-associated endocrine tumors occur in a patient. Up to 10-30 % of those patients have no mutation in the MEN1 gene. It is unclear if the phenotype and course of the disease of mutation-negative patients is comparable with mutation-positive patients and if these patients have true MEN1. The present study aims...
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