Article
Low concentrations of human neutrophil peptide ameliorate experimental murine colitis.
International journal of molecular medicine - 1 Dec 2016
Maeda Takuro, Sakiyama Toshio, Kanmura Shuji, Hashimoto Shinichi, Ibusuki Kazunari, Tanoue Shiroh, Komaki Yuga, Arima Shiho, Nasu Yuichiro, Sasaki Fumisato, Taguchi Hiroki, Numata Masatsugu, Uto Hirofumi, Tsubouchi Hirohito, Ido Akio
Abstract excerpt
Human neutrophil peptides (HNPs) not only have antimicrobial properties, but also exert multiple immunomodulatory effects depending on the concentration used. We have previously demonstrated that the intraperitoneal administration of high-dose HNP-1 (100 µg/day) aggravates murine dextran sulfate sodium (DSS)-induced colitis, suggesting a potential pro-inflammatory role for HNPs at high concentrations. However,...
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