Article
Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson's disease.
Neuroscience - 6 Jan 2017
Zhang Mingming, Mu Hongbo, Shang Zhenwei, Kang Kai, Lv Hongchao, Duan Lian, Li Jin, Chen Xinren, Teng Yanbo, Jiang Yongshuai, Zhang Ruijie
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease. It is generally believed that it is influenced by both genetic and environmental factors, but the precise pathogenesis of PD is unknown to date. In this study, we performed a pathway analysis based on genome-wide association study (GWAS) to detect risk pathways of PD in three GWAS datasets. We first mapped all SNP markers to autosomal...
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