Article
Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor.
Familial cancer - 1 Apr 2017
Goehringer Caroline, Sutter Christian, Kloor Matthias, Gebert Johannes, Slater Emily P, Keller Monika, Treiber Irmgard, Ganschow Petra, Kadmon Martina, Moog Ute
Abstract excerpt
We report on three brothers affected by pancreatic tumors, all due to different causes, including mutations associated with two different cancer predisposition syndromes in the same individual. In the index patient a germline mutation both in the APC and BRCA2 gene was identified while one affected brother showed the BRCA2 mutation only and another brother is supposed to have developed pancreatic cancer due to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.