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Article

Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles

19 Oct 2017

Abstract excerpt

ABSTRACT Efficient antiviral immunity requires interference with virus replication at multiple layers targeting diverse steps in the viral life cycle. We describe here a novel flavivirus inhibition mechanism that results in interferon-mediated obstruction of tick-borne encephalitis virus particle assembly and involves release of malfunctioning membrane-associated capsid (C) particles. This mechanism is controlled...

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Identifiers

PMID: 29046456
DOI: 10.1128/jvi.01751-17

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