Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.

Blood - 26 Jul 2012

Nasr Najla, Maddocks Susan, Turville Stuart G, Harman Andrew N, Woolger Natalie, Helbig Karla J, Wilkinson John, Bye Chris R, Wright Thomas K, Rambukwelle Dharshini, Donaghy Heather, Beard Michael R, Cunningham Anthony L

Abstract excerpt

Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendritic cells and CD4 T cells, without inducing any interferons. Inhibition of type I interferon induction was mediated by HIV-1 inhibition of interferon-regulated factor (IRF3) nuclear translocation. In MDMs, viperin was the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Interferons

Share to Monocytes

Share to Oxidoreductases Acting on CH-CH Group Donors

Share to Protein Prenylation

Share to RNA, Small Interfering

Source

Identifiers

PMID: 22677126
DOI: 10.1182/blood-2012-01-407395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.PMID 22677126Read ↗

Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell TypesSemantic proximity Read ↗

The Interferon Inducible Gene: ViperinSemantic proximity Read ↗

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirusSemantic proximity Read ↗

Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of ViperinSemantic proximity Read ↗

Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid ParticlesSemantic proximity Read ↗

Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?Semantic proximity Read ↗

The Role of Viperin in the Innate Antiviral ResponseSemantic proximity Read ↗

Equine Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting the Production and/or Release of Viral Gag, Env, and Receptor via Distortion of the Endoplasmic ReticulumSemantic proximity Read ↗

Viperin restricts chikungunya virus replication and pathologySemantic proximity Read ↗

Viperin Reveals Its True FunctionSemantic proximity Read ↗

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5ASemantic proximity Read ↗

Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.