Article
Studies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase II-Alpha Interaction with Amsacrine and Mitoxantrone: An In Silico Approach.
Current cancer drug targets - 1 Jan 2017
Farsani Farzaneh Mohamadi, Ganjalikhany Mohamad Reza, Vallian Sadeq
Abstract excerpt
BACKGROUND: DNA topoisomerase II-α (Top2-α), an essential enzyme for the management of DNA during replication, transcription, recombination, and chromatin remodeling, is one of the most important anticancer targets. Numerous molecules have been designed as Top2-α inhibitors. However, several studies have shown that polymorphisms and mutations in Top2 have conferred resistance to most of these anticancer drugs....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.