Article
Spatiotemporal dynamics of the calcineurin target CrzA.
Cellular signalling - 1 Jan 2017
Hernández-Ortiz Patricia, Espeso Eduardo A
Abstract excerpt
The response of Aspergilli to elevated concentrations of extracellular calcium and manganese, or environmental alkalinization is mediated by CrzA, a calcineurin-responsive transcription factor (TF). CrzA is the effector of a signaling pathway which includes the apical protein's calmodulin and calcineurin, and the protein kinases GskA and CkiA. Preferentially located in the cytoplasm, CrzA is the only element of...
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