Gender-dependent and age-of-onset-specific association of the rs11675434 single-nucleotide polymorphism near TPO with susceptibility to Graves' ophthalmopathy.

doi:10.1038/jhg.2016.135

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Article

Gender-dependent and age-of-onset-specific association of the rs11675434 single-nucleotide polymorphism near TPO with susceptibility to Graves' ophthalmopathy.

Journal of human genetics - 1 Mar 2017

Kuś Aleksander, Szymański Konrad, Jurecka-Lubieniecka Beata, Pawlak-Adamska Edyta, Kula Dorota, Miśkiewicz Piotr, Bolanowski Marek, Płoski Rafał, Bossowski Artur, Daroszewski Jacek, Jarząb Barbara, Bednarczuk Tomasz

Abstract excerpt

The role of TPO gene polymorphism in the susceptibility to Graves' disease (GD) remains unclear. However, single-nucleotide polymorphisms (SNPs) near TPO have been recently associated with serum levels of thyroid peroxidase (TPO) antibody in two independent genome-wide association studies. Moreover, we have observed a strong association between the rs11675434 SNP located near TPO and the presence of clinically...

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PMID: 27829681
DOI: 10.1038/jhg.2016.135

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