Article
Uptake of prenatal diagnostic testing for retinoblastoma compared to other hereditary cancer syndromes in the Netherlands.
Familial cancer - 1 Apr 2017
Dommering Charlotte J, Henneman Lidewij, van der Hout Annemarie H, Jonker Marianne A, Tops Carli M J, van den Ouweland Ans M W, van der Luijt Rob B, Mensenkamp Arjen R, Hogervorst Frans B L, Redeker Egbert J W, de Die-Smulders Christine E M, Moll Annette C, Meijers-Heijboer Hanne
Abstract excerpt
Since the 1980s the genetic cause of many hereditary tumor syndromes has been elucidated. As a consequence, carriers of a deleterious mutation in these genes may opt for prenatal diagnoses (PND). We studied the uptake of prenatal diagnosis for five hereditary cancer syndromes in the Netherlands. Uptake for retinoblastoma (Rb) was compared with uptake for Von Hippel-Lindau disease (VHL), Li-Fraumeni syndrome...
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