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Article

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

PloS one - 1 Jan 2016

Sekine Yusuke, Zyryanova Alisa, Crespillo-Casado Ana, Amin-Wetzel Niko, Harding Heather P, Ron David

Abstract excerpt

The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation of the kinase PERK and the resultant phosphorylation of eIF2's alpha subunit (eIF2α) attenuates eIF2B GEF activity thereby inducing an integrated stress response (ISR) that defends against...

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Source

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Identifiers

PMID: 27812215
DOI: 10.1371/journal.pone.0166278
PMCID: PMC5094784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.PMID 27812215Read ↗

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