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Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells

2 Nov 2016

Abstract excerpt

Myocardial injury results in a loss of contractile tissue mass that, in the absence of efficient regeneration, is essentially irreversible. Transplantation of human pluripotent stem cell-derived cardiomyocytes has beneficial but variable effects. We created human engineered heart tissue (hEHT) strips from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and hiPSC-derived endothelial cells. The...

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PMID: 27807283
DOI: 10.1126/scitranslmed.aaf8781

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