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Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function

3 Nov 2016

Abstract excerpt

Whether influenza virus replication in macrophages is productive or abortive has been a topic of debate. Utilizing a panel of 28 distinct human, avian, and swine influenza viruses, we found that only a small subset can overcome cellular blocks to productively replicate in murine and primary human macrophages. Murine macrophages have two cellular blocks. The first block is during viral entry, where virions with...

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PMID: 27807237
DOI: 10.1128/jvi.01417-16

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