Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.

doi:10.1371/journal.pone.0165567

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Article

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.

PloS one - 1 Jan 2016

Fjeld Karianne, Beer Sebastian, Johnstone Marianne, Zimmer Constantin, Mössner Joachim, Ruffert Claudia, Krehan Mario, Zapf Christian, Njølstad Pål Rasmus, Johansson Stefan, Bugert Peter, Miyajima Fabio, Liloglou Triantafillos, Brown Laura J, Winn Simon A, Davies Kelly, Latawiec Diane, Gunson Bridget K, Criddle David N, Pirmohamed Munir, Grützmann Robert, Michl Patrick, Greenhalf William, Molven Anders, Sutton Robert, Rosendahl Jonas

Abstract excerpt

BACKGROUND: Carboxyl-ester lipase (CEL) contributes to fatty acid ethyl ester metabolism, which is implicated in alcoholic pancreatitis. The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11. Variation in this VNTR has been linked to monogenic pancreatic disease, while conflicting results were reported for chronic pancreatitis (CP). Here, we aimed to investigate a potential...

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PMID: 27802312
DOI: 10.1371/journal.pone.0165567
PMCID: PMC5089759

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Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.PMID 27802312Read ↗

Homozygosity of short VNTR lengths in the CEL gene may confer susceptibility to idiopathic chronic pancreatitis.Semantic proximity Read ↗

Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis.Semantic proximity Read ↗

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.Semantic proximity Read ↗

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas.Semantic proximity Read ↗

Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.Semantic proximity Read ↗

Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.Semantic proximity Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.Semantic proximity Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase ( <i>CEL</i> ) gene determines pathogenicitySemantic proximity Read ↗

A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.Semantic proximity Read ↗

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Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis.Semantic proximity Read ↗

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.Semantic proximity Read ↗

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