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Article

Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice.

Birth defects research - 20 Jan 2017

Fish Eric W, Parnell Scott E, Sulik Kathleen K, Baker Lorinda K, Murdaugh Laura B, Lamson David, Williams Kevin P

Abstract excerpt

BACKGROUND: While pharmacological activation of the Hedgehog (HH) signaling pathway may have therapeutic benefits for developmental and adult diseases, its teratogenic potential is of concern. The membrane molecule Smoothened (SMO) transduces HH signaling and can be acutely modulated by antagonists and agonists. The objective of the current experiments was to determine how maternal treatment with the Smo agonist,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27801979
DOI: 10.1002/bdra.23571
PMCID: PMC5388559

Genes

SAG
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice.PMID 27801979Read ↗

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