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INTEGRATE-neo: a pipeline for personalized gene fusion neoantigen discovery

21 Oct 2016

Abstract excerpt

Motivation: While high-throughput sequencing (HTS) has been used successfully to discover tumor-specific mutant peptides (neoantigens) from somatic missense mutations, the field currently lacks a method for identifying which gene fusions may generate neoantigens. Results: We demonstrate the application of our gene fusion neoantigen discovery pipeline, called INTEGRATE-Neo, by identifying gene fusions in prostate...

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PMID: 27797777
DOI: 10.1093/bioinformatics/btw674

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