Article
Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2017
Liao Katherine P, Sparks Jeffrey A, Hejblum Boris P, Kuo I-Hsin, Cui Jing, Lahey Lauren J, Cagan Andrew, Gainer Vivian S, Liu Weidong, Cai T Tony, Sokolove Jeremy, Cai Tianxi
Abstract excerpt
OBJECTIVE: Patients with rheumatoid arthritis (RA) develop autoantibodies against a spectrum of antigens, but the clinical significance of these autoantibodies is unclear. Using a phenome-wide association study (PheWAS) approach, we examined the association between autoantibodies and clinical subphenotypes of RA. METHODS: This study was conducted in a cohort of RA patients identified from the electronic medical...
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