Article
Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms.
Neuroscience - 6 Jan 2017
Zoratto Francesca, Romano Emilia, Pascale Esterina, Pucci Mariangela, Falconi Anastasia, Dell'Osso Bernardo, Maccarrone Mauro, Laviola Giovanni, D'Addario Claudio, Adriani Walter
Abstract excerpt
Gambling Disorder (GD) is characterized by excessive gambling despite adverse consequences on individual functioning. In spite of some positive findings, it is difficult to draw any conclusion on the genetics of GD. Indeed, beyond DNA sequence variation, other regulatory mechanisms (like those that engage epigenetics) may explain gene alterations in this addictive disease. Wistar male rats underwent an operant...
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