Article
HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women.
Journal of gastroenterology and hepatology - 1 Apr 2017
Warne Charles D, Zaloumis Sophie G, Bertalli Nadine A, Delatycki Martin B, Nicoll Amanda J, McLaren Christine E, Hopper John L, Giles Graham G, Anderson Greg J, Olynyk John K, Powell Lawrie W, Allen Katrina J, Gurrin Lyle C
Abstract excerpt
BACKGROUND AND AIM: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy. We used data from a population cohort study to model the impact of menstruation cessation at menopause on serum ferritin (SF) levels in female p.C282Y homozygotes,...
Topics
- Adult
- Aged
- Australia
- Cohort Studies
- Female
- Ferritins
- Genetic Predisposition to Disease
- Genotype
- Hemochromatosis
- Hemochromatosis Protein
- Homozygote
- Humans
- Menopause