Article
The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.
Gastroenterology - 1 Dec 2008
Gurrin Lyle C, Osborne Nicholas J, Constantine Clare C, McLaren Christine E, English Dallas R, Gertig Dorota M, Delatycki Martin B, Southey Melissa C, Hopper John L, Giles Graham G, Anderson Gregory J, Olynyk John K, Powell Laurie W, Allen Katrina J
Abstract excerpt
BACKGROUND & AIMS: There are few longitudinal studies of serum ferritin (SF) and transferrin saturation (TS) levels in individuals homozygous for the C282Y mutation. We characterized the development of elevated iron measures in C282Y homozygotes followed for 12 years. METHODS: From 31,192 people aged 40-69 years at baseline, we identified 203 C282Y homozygotes (95 males), of whom 116 had SF and fasting TS levels...
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