Article
Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery.
Cancer biology & therapy - 1 Jan 2008
Tan Aik Choon, Fan Jian-Bing, Karikari Collins, Bibikova Marina, Garcia Eliza Wickham, Zhou Lixin, Barker David, Serre David, Feldmann Georg, Hruban Ralph H, Klein Alison P, Goggins Michael, Couch Fergus J, Hudson Thomas J, Winslow Raimond L, Maitra Anirban, Chakravarti Aravinda
Abstract excerpt
Physiologic allele-specific expression (ASE) in germline tissues occurs during random X-chromosome inactivation and in genomic imprinting, wherein the two alleles of a gene in a heterozygous individual are not expressed equally. Recent studies have confirmed the existence of ASE in apparently non-imprinted autosomal genes; however, the extent of ASE in the human genome is unknown. We explored ASE in...
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