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Article

Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.

Breast cancer research and treatment - 1 Jan 2017

Kim Haeyoung, Cho Dae-Yeon, Choi Doo Ho, Oh Mijin, Shin Inkyung, Park Won, Huh Seung Jae, Nam Seok Jin, Lee Jeong Eon, Kim Seok Won

Abstract excerpt

PURPOSE: This study was performed to evaluate the frequency of mutations in CHEK2, PALB2, MRE11, and RAD50 among Korean patients at high risk for hereditary breast cancer. METHODS: A total of 235 Korean patients with hereditary breast cancer who tested negative for BRCA1/2 mutation were enrolled to this study. Entire coding regions of CHEK2, PALB2, MRE11, and RAD50 were analyzed using massively parallel...

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Source

Identifiers

PMID: 27783279
DOI: 10.1007/s10549-016-4034-2

Genes

PALB2
RAD50
CHEK2
MRE11
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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