Article
Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor.
PloS one - 1 Jan 2016
Dahlin Anna M, Wibom Carl, Ghasimi Soma, Brännström Thomas, Andersson Ulrika, Melin Beatrice
Abstract excerpt
Genome-wide association studies and candidate gene studies have identified several genetic variants that increase glioma risk. The majority of these variants are non-coding and the mechanisms behind the increased risk in carriers are not known. In this study, we hypothesize that some of the established glioma risk variants induce aberrant DNA methylation in the developing tumor, either locally (gene-specific) or...
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