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Article

HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.

Scientific reports - 25 Oct 2016

Chen Lubiao, Gu Lin, Gu Yurong, Wang Hongbo, Deng Meihai, Stamataki Zania, Oo Ye Htun, Huang Yuehua

Abstract excerpt

Mutations in the hepatitis B virus (HBV) core promoter (CP) have been shown to be associated with hepatocellular carcinoma (HCC). The CP region overlaps HBV X gene, which activates AKT to regulate hepatocyte survival. However, the cooperation between these two cascades in HCC progression remains...

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Share to Carcinoma, Hepatocellular
Share to Disease Progression
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Oncogene Protein v-akt

Share to Promoter Regions, Genetic

Share to S-Phase Kinase-Associated Proteins

Source

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Identifiers

PMID: 27779207
DOI: 10.1038/srep35917
PMCID: PMC5078796

Genes

SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-27779207-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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