Article
The hepatitis B virus X protein promotes pancreatic cancer through modulation of the PI3K/AKT signaling pathway.
Cancer letters - 28 Sept 2016
Chen Yiwen, Bai Xueli, Zhang Qi, Wen Liang, Su Wei, Fu Qihan, Sun Xu, Lou Yu, Yang Jiaqi, Zhang Jingying, Chen Qi, Wang Jianxin, Liang Tingbo
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis for PDAC patients; however, the mechanisms involved in this process are unclear. We evaluated whether HBV infection leads to PDAC with a more aggressive phenotype, and attempted to elucidate the mechanisms involved. Clinicopathological...
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