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Interstitial flow differentially increases patient-derived glioblastoma stem cell invasionviaCXCR4, CXCL12, and CD44-mediated mechanisms

18 Oct 2016

Abstract excerpt

Glioblastoma (GBM) prognosis remains dismal due in part to the invasiveness of GBM cells. Interstitial fluid flow (IFF) has been shown to increase invasion of glioma cells in vitro through the CXCR4 receptor interacting with autologous, pericellular gradients of CXCL12 (autologous chemotaxis) or through the CD44 receptor interactions with the extracellular matrix (hyaluronan-mediated mechanotransduction). These...

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PMID: 27775742
DOI: 10.1039/c6ib00167j

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