Article
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations.
Hepatology (Baltimore, Md.) - 1 Jan 2017
Ke Shizhong, Chen Shuzhen, Dong Zihui, Hong Christopher S, Zhang Qi, Tang Liang, Yang Pinghua, Zhai Jian, Yan Hexin, Shen Feng, Zhuang Zhengping, Wen Wen, Wang Hongyang
Abstract excerpt
Erythrocytosis is a common paraneoplastic syndrome associated with hepatocellular carcinoma. Although increased erythropoietin (EPO) is found in these patients, the clinical significance and molecular mechanisms underlying this observation are unclear. We demonstrate an inverse relationship between EPO production and overall prognosis in our cohort of 664 patients as well as in data from The Cancer Genome Atlas....
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