Article
Gene expression of mutant erythropoietin in hepatocellular carcinoma.
Biochemical and biophysical research communications - 15 Sept 1993
Funakoshi A, Muta H, Baba T, Shimizu S
Abstract excerpt
A case of hepatocellular carcinoma complicated by erythrocytosis showed an increased level of serum immunoreactive erythropoietin (EPO) and EPO bioactivity. RT-PCR (reverse transcriptase and polymerase chain reaction) of EPO mRNA extracted from a surgical specimen indicated high expression of EPO mRNA in the tumor tissue. The nucleotide sequences of PCR amplified regions of the EPO precursor mRNA in tumor tissue...
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